| 有机溶剂-水双液相体系脂肪酶不对称水解合成S-(+)-萘普生 |
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| 引用本文： | 辛嘉英,李树本,徐毅,沈润南,尉迟力.有机溶剂-水双液相体系脂肪酶不对称水解合成S-(+)-萘普生[J].分子催化,1998(6). |
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| 作者姓名： | 辛嘉英 李树本 徐毅 沈润南 尉迟力 |
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| 作者单位： | 中国科学院兰州化学物理研究所羰基合成与选择氧化国家重点实验室 |
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| 摘 要： | 采用有机溶剂－水双液相体系作为反应介质，并用键合有—Ｃ６Ｈ５的无定型多孔硅胶作为分散剂增大两相间的接触面，用圆柱状假丝酵母脂肪酶对萘普生甲酯进行不对称水解．考察了酶浓度、体系ｐＨ值、温度、分散剂对反应的影响．当转化率为２４．３％时，产品萘普生的对映体过量值（ｅｅ）为９４．９％，剩余底物萘普生甲酯的对映体过量值（ｅｅ）为３０．５％，当以异辛烷作为有机相时，该体系酶催化水解的对映体比率（Ｅ）约为５０．
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| 关 键 词： | 有机溶剂－水双液相体系 脂肪酶 萘普生 酶法拆分 不对称水解 |
Synthesis of S (+) Naproxen by Lipase Asymmetric Hydrolysis in an Aqueous Organic Solvent Biphase System |
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| XIN Jiaying,LI Shuben,XU Yi,SHEN Runnan,YU Chili.Synthesis of S (+) Naproxen by Lipase Asymmetric Hydrolysis in an Aqueous Organic Solvent Biphase System[J].Journal of Molecular Catalysis (China),1998(6). |
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| Authors: | XIN Jiaying LI Shuben XU Yi SHEN Runnan YU Chili |
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| Institution: | State Key Laboratory for OXO Synthesis and Selective Oxidation Lanzhou Institute of Chemical Physics The Chinese Academy of Sciences Lanzhou 730000 |
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| Abstract: | The enzymatic resolution of ( R,S ) naproxen was accomplished by treatment of naproxen methyl ester in an aqueous organic solvent biphase system with a number of commericially available Candida rugosa lipase. The effects of lipase concentration, dispersing agent, temperature and pH value on reaction conversion have been studied. With isooctanes as organic phase,0.2 mol/L phosphate buffer as aqueous phase and 2%YWG C 6H 5 as dispersing agent, 94.9% enantiomeric excess could be obtained at 24.3% conversion of naproxen methylester. |
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| Keywords: | Organic solvent aqueous biphase system Lipase Naproxen Enzymatic resolution Asymmetric hydrolysis |
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