Synthesis of photoactive p-azidotetrafluorophenylalanine containing peptide by solid-phase Fmoc methodology |
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| Authors: | Redman James E Ghadiri M Reza |
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| Affiliation: | Department of Chemistry, The Scripps Research Institute, La Jolla, California 92037, USA. |
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| Abstract: | [structure: see text] N-Fmoc-L-p-azidotetrafluorophenylalanine was prepared from achiral starting materials using an acetamidomalonate synthesis and enzymatic resolution. A photoactive peptide containing this fluorinated residue could be assembled using solid-phase Fmoc chemistry. |
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