A new strategy toward the total synthesis of stachyflin,a potent anti-influenza A virus agent: concise route to the tetracyclic core structure |
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Authors: | Nakatani Mari Nakamura Masahiko Suzuki Akiyuki Inoue Munenori Katoh Tadashi |
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Institution: | Sagami Chemical Research Center, Hayakawa 2743-1, Ayase, Kanagawa 252-1193, Japan. |
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Abstract: | reaction: see text] A new strategy directed toward the total synthesis of stachyflin, a potent and novel anti-influenza A virus agent isolated from a microorganism, has been presented through the enantioselective synthesis of the tetracyclic core structure. The synthetic method features a BF(3) x Et(2)O-induced domino epoxide-opening/rearrangement/cyclization reaction as the key step. |
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