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Stereocalpin A, a bioactive cyclic depsipeptide from the Antarctic lichen Stereocaulon alpinum |
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| Authors: | Changon Seo Hong Kum Lee Jae-Hak Sohn |
| Affiliation: | a College of Medical and Life Sciences, Silla University, Busan 617-736, Republic of Korea b Korea Polar Research Institute, KORDI, Incheon 406-840, Republic of Korea c Industry-University Cooperation Foundation, Pukyong National University, Busan 608-739, Republic of Korea |
| Abstract: | A new cyclic depsipeptide stereocalpin A (1) has been isolated from the MeOH extract of the Antarctic lichen Stereocaulon alpinum by various chromatographic methods. The structure of stereocalpin A (1) was mainly determined by analysis of the NMR spectroscopic data and by chemical methods. Stereocalpin A (1) is a unique cyclic peptide incorporating an unprecedented 5-hydroxy-2,4-dimethyl-3-oxo-octanoic acid in the structure. Stereocalpin A (1) shows moderate cytotoxicity against three human solid tumor cell lines. |
| Keywords: | Stereocaulon alpinum Stereocalpin A Cyclic depsipeptide Cytotoxicity |
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