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One-pot synthesis of trisubstituted pyrazoles |
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| Authors: | P.?Santhosh,V.?S.?R.?Chunduru,V.?Rajeswar?Rao author-information" > author-information__contact u-icon-before" > mailto:vrajesw@yahoo.com" title=" vrajesw@yahoo.com" itemprop=" email" data-track=" click" data-track-action=" Email author" data-track-label=" " >Email author |
| Affiliation: | (1) Department of Chemistry, National Institute of Technology, Warangal, 506 004, A.P, India; |
| Abstract: | An efficient one-pot multicomponent reaction for the synthesis of 1-aryl- or 1-heteryl-substituted 3,5-dimethylpyrazoles with excellent yields has been described. Reaction of 3-(2-bromoacetyl)coumarins or phenacyl bromides with acetylacetone and hydrazine hydrate in ethanol afforded the corresponding 3,5-dimethylpyrazoles in good yields. All the synthesized compounds were characterized by their analytical and spectral data. |
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