Synthesis of hexacyclic fused isocoumarin framework through selective domino multicyclizations under catalyst and solvent free conditions |
| |
Authors: | Tariq Mahmood Babar, Muhammad Moazzam Naseer, Muhammad Khawar Rauf, Humayun Pervez, Masahiro Ebihara, Nasim Hasan Rama |
| |
Affiliation: | a Department of Chemistry, Quaid-i-Azam University, Islamabad 45320, Pakistan;b Institute of Chemical Sciences, Organic Chemistry Division, Bahauddin Zakariya University, Multan 60800, Pakistan;c Department of Chemistry, Faculty of Engineering, Gifu University, Yanagido, Gifu 501-1193, Japan |
| |
Abstract: | A novel fused isocoumarin skeleton has been synthesized through selective domino multicyclizations by mixing homothallic acid and 2,3-diphenylacryloyl chloride at 200 8C under catalyst and solvent free reaction conditions.Six fused rings with two stereogenic centers were assembled in a convenient onepot operation in good yield.The resulting hexacyclic fused isocoumarin skeleton and its stereochemistry was fully characterized and unambiguously confirmed by X-ray diffraction analysis. |
| |
Keywords: | Hexacyclic Fused isocoumarin One pot Catalyst and solvent free |
本文献已被 CNKI 维普 ScienceDirect 等数据库收录! |
| 点击此处可从《中国化学快报》浏览原始摘要信息 |
|
点击此处可从《中国化学快报》下载全文 |
|