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Synthesis of hexacyclic fused isocoumarin framework through selective domino multicyclizations under catalyst and solvent free conditions |
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| Authors: | Tariq Mahmood Babar ;Muhammad Moazzam Naseer ;Muhammad Khawar Rauf ;Humayun Pervez ;Masahiro Ebihara ;Nasim Hasan Rama |
| Institution: | a Department of Chemistry, Quaid-i-Azam University, Islamabad 45320, Pakistan; b Institute of Chemical Sciences, Organic Chemistry Division, Bahauddin Zakariya University, Multan 60800, Pakistan; c Department of Chemistry, Faculty of Engineering, Gifu University, Yanagido, Gifu 501-1193, Japan |
| Abstract: | A novel fused isocoumarin skeleton has been synthesized through selective domino multicyclizations by mixing homothallic acid and 2,3-diphenylacryloyl chloride at 200 8C under catalyst and solvent free reaction conditions.Six fused rings with two stereogenic centers were assembled in a convenient onepot operation in good yield.The resulting hexacyclic fused isocoumarin skeleton and its stereochemistry was fully characterized and unambiguously confirmed by X-ray diffraction analysis. |
| Keywords: | Hexacyclic Fused isocoumarin One pot Catalyst and solvent free |
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