Nickel-catalyzed cross-coupling reaction of alkynyl bromides with Grignard reagents

We describe a convenient method for the synthesis of 1,2-disubstituted acetylenes via a cross-coupling reaction of(bromoethynyl)benzene with Grignard reagents.The reaction of(bromoethynyl)benzene(1 mmol) with Grignard reagent(1.3 mmol) mediated by NiCl2(4 mol%) and(p-CH3Ph)3P(8 mol%) in THF could produce 1,2-disubstituted acetylenes in good yields at room temperature.