Origins of the high 14-helix propensity of cyclohexyl-rigidified residues in beta-peptides |
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| Authors: | Lee Myung-Ryul Raguse Tami L Schinnerl Marina Pomerantz William C Wang Xiaodong Wipf Peter Gellman Samuel H |
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| Institution: | Department of Chemistry, University of Wisconsin, Madison, Wisconsin 53706, USA. |
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| Abstract: | structure: see text] beta-Peptides containing residues derived from trans-2-aminocyclohexanecarboxylic acid (ACHC) display high population of 14-helical secondary structure in aqueous solution. We show that hydrophobic interactions between cyclohexyl rings are not responsible for this conformation-promoting effect, and that polar groups may be attached to the cyclohexyl ring without diminishing the effect. |
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