| Crystal Structure of Sar1[H79G]-GDP Which Provides Insight into the Coat-controlled GTP Hydrolysis in the Disassembly of COP Ⅱ |
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| 引用本文： | RAO Yi-Jian YUAN Cai BIAN Chuan-Bing HOU Xiao-Min LI Yong-Dong ZHAO Geng-Xiang YE Xiao-Ming HUANG Zi-Xiang HUANG Ming-Dong ②.Crystal Structure of Sar1[H79G]-GDP Which Provides Insight into the Coat-controlled GTP Hydrolysis in the Disassembly of COP Ⅱ[J].结构化学,2006,25(7):854-860. |
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| 作者姓名： | RAO Yi-Jian YUAN Cai BIAN Chuan-Bing HOU Xiao-Min LI Yong-Dong ZHAO Geng-Xiang YE Xiao-Ming HUANG Zi-Xiang HUANG Ming-Dong ② |
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| 作者单位： | State Key Laboratory of Structural Chemistry，Fujian Institute of Research on the Structure of Matter，The Chinese Academy of Sciences，Fuzhou，Fujian 350002，China |
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| 基金项目： | This work was supported by the Frontier Interdisciplinary Innovation Fund from Fujian Institute of Research on the Structure of Matter, and Hundred Talents Project of Chinese Academy of Sciences |
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| 摘 要： | 1 INTRODUCTION The selective export of cargoes from the endore- ticulum is an evolutionarily conserved function cen- tral to cell development and proliferation. This ex- port is regulated by the Sar1 GTPase, a member of the Ras superfamily of small GTPases1~4]. Like other Ras proteins, Sar1 functions as binary switches by cycling between inactive GDP- and active GTP- bound states5]. The conversion of Sar1-GDP to Sar1- GTP following receptor activation is catalyzed by guanine nu…
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| 关 键 词： | Sarl switch Ⅱ COP Ⅱ disassembly crystal structure |
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