Pseudohypericin and hypericin in St. John's wort extracts. Breakdown of pseudohypericin |
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| Institution: | 1. Gustave-Roussy, Inserm U981, Gynecological Tumors Translational Research Lab, 114, rue Edouard-Vaillant, B2M - p130, 94805 Villejuif, France;2. University Paris-Saclay, Gustave Roussy Cancer Center, Department of Medical Oncology, 94805 Villejuif, France;1. Biotechnology, Bioprocess and Biocatalysis Group, Institute of Food Science and Technology, Federal University of Rio Grande do Sul, Av. Bento Gonçalves, 9500, P.O. Box 15090, ZC 91501-970, Porto Alegre, RS, Brazil;2. Beverages Technology Lab, Institute of Food Science and Technology, Federal University of Rio Grande do Sul, Brazil;1. Department of Chemical Engineering, Laval University, 1065 Avenue de la Médecine, Quebec, QC G1V0A6, Canada;2. Centre for Nano and Material Sciences, Jain University, Bangalore, 562112, Karnataka, India;3. Valcartier Research Centre, Defence Research and Development, Canada |
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| Abstract: | Photodiode array detector-coupled HPLC analysis of extracts of St. John's wort (Hypericum perforatum) reveals two main compounds: pseudohypericin (PH) and hypericin (H) (peaks A and B respectively). When the pH of the extracts is raised, peak A irreversibly disappears whereas peak B does not change. This instability at high pH means that alkaline conditions should be avoided during extraction and raises a question concerning the bioavailability of pseudohypericin from St. John's wort extract-containing medicinal products designed for oral administration. |
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