Metathesis reactions of pyrazolotriazinones generate dynamic combinatorial libraries |
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| Authors: | Wipf Peter Mahler S Graciela Okumura Kazuo |
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| Institution: | Department of Chemistry, University of Pittsburgh, Pittsburgh, Pennsylvania 15260, USA. pwipf@pitt.edu |
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| Abstract: | reaction: see text] Reversible metathesis reactions of pyrazolotriazinones and aliphatic aldehydes or ketones proceed in aqueous, phosphate-buffered media at pH 4 and 40-60 degrees C to generate thermodynamically controlled mixtures of heterocycles. |
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