S-benzoxazolyl as a stable protecting moiety and a potent anomeric leaving group in oligosaccharide synthesis |
| |
Authors: | Kamat Medha N De Meo Cristina Demchenko Alexei V |
| |
Institution: | Department of Chemistry and Biochemistry, University of Missouri-St. Louis, One University Boulevard, St. Louis, Missouri 63121, USA. |
| |
Abstract: | As a part of a program for developing new versatile building blocks for stereoselective glycosylation and convergent oligosaccharide synthesis, we demonstrated that S-benzoxazolyl (SBox) glycosides are stable toward major protecting group manipulations employed in carbohydrate chemistry. On the other hand, they can be glycosidated under relatively mild reaction conditions to afford either 1,2-trans or 1,2-cis-linked disaccharides. Selective and chemoselective activations of the SBox moiety were also proved to be feasible, which was demonstrated by synthesizing a number of oligosaccharide sequences. |
| |
Keywords: | |
本文献已被 PubMed 等数据库收录! |
|