2-(2-furyl)imidazo[1,2-a]pyrimidine synthesis and electrophilic substitution reactions

The synthesis of 2-(2-furyl)imidazo[1,2-a]pyrimidine has been carried out. Azocoupling, nitrosation, and bromination by 1 mole of bromine occur at position 3 of the bicycle. Reaction with 2 mol of bromine gives the 3,5‰-disubstituted derivative. Bromination using 1 mol of bromine in 40% hydrobromic acid and sulfonation occur initially at the 5‰ position of the furyl group. __________ Translated from Khimiya Geterotsiklicheskikh Soedinenii, No. 4, pp. 565–570, April, 2006.