Synthesis of <Emphasis Type="Italic">N</Emphasis>-(2-chloroethyl)glycine and -<Emphasis Type="SmallCaps">DL</Emphasis>-alanine esters期刊界 All Journals 搜尽天下杂志传播学术成果专业期刊搜索期刊信息化学术搜索

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Synthesis of <Emphasis Type="Italic">N</Emphasis>-(2-chloroethyl)glycine and -<Emphasis Type="SmallCaps">DL</Emphasis>-alanine esters

Authors:	I M Aladzheva O V Bykhovskaya P V Petrovskii T A Mastryukova

Institution:	(1) A. N. Nesmeyanov Institute of Organoelement Compounds, Russian Academy of Sciences, 28 ul. Vavilova, 119991 Moscow, Russian Federation

Abstract:	Two methods for the synthesis of N-(2-chloroethyl)glycine and-DL-alanine esters are proposed: 1) reductive amination of the C=O group of glyoxilic or pyruvic acids upon treatment with 2-chloroethylamine and sodium cyanoborohydride in methanol and 2) alkylation of 2-chloroethylamine with α-haloalkanoic acid esters in K₂CO₃-MeCN two-phase system. Published in Russian in Izvestiya Akademii Nauk. Seriya Khimicheskaya, No. 12, pp. 2372–2374, December, 2007.

Keywords:	N-(2-chloroethyl)glycine DL-alanine" target="_blank">N-(2-chloroethyl)-DL-alanine amino acids reductive amination alkylation two-phase systems
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