Sequence-specific synthesis of macromolecules using DNA-templated chemistry |
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| Authors: | Milnes Phillip J McKee Mireya L Bath Jonathan Song Lijiang Stulz Eugen Turberfield Andrew J O'Reilly Rachel K |
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| Institution: | Department of Chemistry, University of Warwick, Coventry, CV4 7AL, UK. |
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| Abstract: | Using a strand exchange mechanism we have prepared, by DNA templated chemistry, two 10-mers with defined and tunable monomer sequences. An optimized reaction protocol achieves 85% coupling yield per step, demonstrating that DNA-templated chemistry is a powerful tool for the synthesis of macromolecules with full sequence control. |
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