A Markov Model for Kinesin |
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Authors: | Christian Maes Maarten H. van Wieren |
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Affiliation: | (1) Instituut voor Theoretische Fysica, K.U. leuven, Celestijnenlaan 200D, B-3001 Leuven, Belgium |
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Abstract: | We investigate the validity of a Markov approach for the motility of kinesin. We show in detail how the various mechanochemical states and reaction rates that are experimentally measured, can be used to create a Markov-chain model. We compare the performance of this model to motility data and we find global similarities in the load and ATP-concentration dependency of speed and mean run length. We also discuss the relation between the experimentally found stalling behavior and thermodynamic expectations. Finally, the Markov chain modelling provides a way to calculate the mean entropy production and the (power) efficiency. |
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Keywords: | biochemical processes molecular motors kinesin |
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