The Chlorhexidine: beta;-Cyclodextrin Inclusion Compound: Preparation, Characterization and Microbiological Evaluation |
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| Authors: | Maria Esperanza Cortés Rubén Dario Sinisterra Mario Julio Avila-Campos Nicolau Tortamano Rodney Garcia Rocha |
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| Affiliation: | (1) Dpto. de Odontologia Restauradora, Faculdade de Odontologia, Universidade Federal de Minas Gerais, Av. Antônio Carlos 6627, CEP, 31270-901 Belo Horizonte, Brazil;(2) Dpto. de Química, ICEX, UFMG, Brazil;(3) Dpto. de Microbiologia, ICB, Brazil;(4) Faculdade de Odontologia, Universidade de São Paulo, Brazil |
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| Abstract: | The 1 : 2 chlorhexidine :  -cyclodextrin(Cx : CD) complex was prepared and characterised using X-ray crystallography, infrared spectroscopy, thermal analysis and nuclearmagnetic resonance. The minimum inhibitory concentration (MIC50) of the chlorhexidine : -cyclodextrin inclusion compoundagainst Streptococcus mutans, Eubacterium Lentum, Fusobacterium nucleatum, Bacteroides fragilis andActinomices actinomycetemcomitans was determined. TheCx : CD inclusion compound inhibited the bacterial growth at a low concentration. |
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| Keywords: | chlorhexidine ![]("</a) /content/w741318704107151/xxlarge946.gif" alt=" beta" align=" MIDDLE" BORDER=" 0" >-cyclodextrin minimum inhibitory concentration |
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