Regioselective C-H Functionalization of the Six-Membered Ring of the 6,5-Fused Heterocyclic Systems: An Overview |
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| Authors: | Soukaina Faarasse,Nabil El Brahmi,Gé rald Guillaumet,Saï d El Kazzouli |
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| Affiliation: | 1.Euromed Research Center, Euromed Faculty of Pharmacy, Euromed University of Fes, Route de Meknes, Fez 30000, Morocco; (S.F.); (N.E.B.); (G.G.);2.Institute of Organic and Analytical Chemistry, University of Orleans, UMR CNRS 7311, BP 6759, CEDEX 2, 45067 Orleans, France |
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| Abstract: | The regioselective C-H functionalization of the five-membered ring of the 6,5-fused heterocyclic systems is nowadays well documented due to its high reactivity compared to the six-membered ring. So, developing new procedures of C-H functionalization of the six-membered ring “by thinking out of the box” is extremely challenging, which explains the limited number of reports published to date. This review paper aims to highlight advances achieved in this emerging chemistry research and discusses recently reported methods. |
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| Keywords: | 6,5-fused heterocyclic systems C-H functionalization C-H/C-H activation direct arylation oxidative alkenylation |
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