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Living Polymerization of α‐Amino Acid N‐Carboxyanhydrides (NCA) upon Decreasing the Reaction Temperature
Authors:Willy Vayaboury  Olivia Giani  Herv Cottet  Andr Deratani  Franois Schu
Abstract:Summary : The n‐hexylamine‐initiated polymerization of Nε‐trifluoroacetyl‐L ‐lysine N‐carboxyanhydride in N,N‐dimethyformamide was studied by nonaqueous capillary electrophoresis. A polypeptide with a broad molecular weight distribution was obtained and side reactions were clearly identified for polymerization at room temperature. The possibility of living polymerization at 0 °C was demonstrated.

Synthesis of living polypeptides by primary amine initiated polymerization of NCA at low temperatures.

Keywords:living polymerization  nonaqueous capillary electrophoresis  peptides  temperature decrease
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