Activity-based profiling for drug discovery |
| |
| Authors: | Serwa Remigiusz Tate Edward W |
| |
| Affiliation: | 1 Institute of Chemical Biology, Department of Chemistry, Imperial College London, South Kensington Campus, London SW7 2AZ, UK |
| |
| Abstract: | Activity-based protein profiling (ABPP) is emerging as a game-changing tool for drug discovery, target validation, and basic biology. In this issue, Chang et?al. (2011) report the ABPP-facilitated discovery of JW480, a highly selective potent and orally bioavailable inhibitor of monoalkylglycerol ether hydrolase KIAA1363 that dramatically impairs in?vivo growth of human prostate cancer cell lines. |
| |
| Keywords: | |
| 本文献已被 ScienceDirect PubMed 等数据库收录！ |
|
