Application of beta-hydroxysulfoximines in catalytic asymmetric phenyl transfer reactions for the synthesis of diarylmethanols |
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Authors: | Sedelmeier Jörg Bolm Carsten |
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Institution: | Institute of Organic Chemistry, RWTH Aachen University, Landoltweg 1, D-52056, Aachen, Germany. |
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Abstract: | Enantiomerically enriched diarylmethanols have been prepared by catalyzed asymmetric phenyl transfer reactions onto aromatic aldehydes with use of readily available beta-hydroxysulfoximines as catalysts. As the aryl source, combinations of diethylzinc with either diphenylzinc or triphenylborane have been applied affording arylphenylmethanols with up to 93% ee in good yields. Various functionalized aldehydes and heterocyclic substrates are tolerated, yielding synthetically relevant products. |
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