| 克力托辛(Clitocine)及其类似物的合成与生物活性 |
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| 引用本文： | 郭翔海,康宏,郑岚曦,姜申德.克力托辛(Clitocine)及其类似物的合成与生物活性[J].有机化学,2011,31(2). |
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| 作者姓名： | 郭翔海 康宏 郑岚曦 姜申德 |
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| 作者单位： | 1. 天津大学化工学院,系统生物工程教育部重点实验室,天津,300072
2. 天津大学药物科学与技术学院,天津,300072 |
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| 摘 要： | 克力托辛是一种从蘑菇Clitocybe inversa中分离出的天然核苷.它及其类似物具有很高的生物活性.综述了克力托辛及2'-脱氧克力托辛类似物、碱基修饰克力托辛类似物、5'-脱氧克力托辛类似物、碳环克力托辛类似物以及无环克力托辛类似物的合成方法,并对克力托辛及其类似物在农业害虫杀灭、腺苷激酶抑制剂、抗肿瘤、抗病毒等药物研究中的应用进行了概述.
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| 关 键 词： | 克力托辛 合成 核苷类似物 抗病毒 抗肿瘤 |
Synthetic Methods and Biological Activities of Clitocine and Its Analogues |
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| Guo Xianghai,Kang Hong,Zheng Lanxi,Jiang Shende.Synthetic Methods and Biological Activities of Clitocine and Its Analogues[J].Chinese Journal of Organic Chemistry,2011,31(2). |
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| Authors: | Guo Xianghai Kang Hong Zheng Lanxi Jiang Shende |
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| Institution: | Guo,Xianghai*,a Kang,Hongb Zheng,Lanxib Jiang,Shende*,b(a Key Laboratory of Systems Bioengineering,Ministry of Education,School of Chemical Engineering and Technology,Tianjin University,Tianjin 300072)(b School of Pharmaceutical Science and Technology,Tianjin 300072) |
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| Abstract: | Clitocine is a naturally occurring amino exocyclic nucleoside isolated from the mushroom Clitocybe inversa.It and its analogues have high bioactivities.In this review,the synthetic methods of clito-cine,2'-deoxy clitocine,aglycone-modified clitocine,5'-deoxy clitocine,carbosugar clitocine and acyclic clitocine analogues are summarized.The application of clitocine and its analogues to study on insecticidal agent,adenosine kinase(AKase) inhibitor,antiviral and antitumor drugs is presented as well. |
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| Keywords: | clitocine synthesis nucleoside analogue antiviral antitumor |
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