| 5-(4-叔丁氧基羰基哌嗪基)苯并呋喃-2-甲酸乙酯的合成 |
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| 引用本文： | 封静,王成云,周长凯,左虎进,沈永嘉. 5-(4-叔丁氧基羰基哌嗪基)苯并呋喃-2-甲酸乙酯的合成[J]. 有机化学, 2011, 31(2) |
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| 作者姓名： | 封静 王成云 周长凯 左虎进 沈永嘉 |
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| 作者单位： | 华东理工大学结构可控先进功能材料及其制备教育部重点实验室,精细化工研究所,上海,200237 |
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| 摘 要： | 5-溴苯并呋喃-2-甲酸乙酯与4-叔丁氧基羰基哌嗪进行Buchwald-Hartwig偶联反应,若催化剂是Pd(OAc)2/BINAP,碱是Cs2CO3,则产物主要是5-(4-叔丁氧基羰基哌嗪基)苯并呋喃-2-甲酸乙酯,转化率达70%;若催化剂是Pd(dba)2/P(t-Bu)3,碱是叔丁醇钾,则产物中几乎没有5-(4-叔丁氧基羰基哌嗪基)苯并呋喃-2-甲酸乙酯.文中讨论了影响这个Buchwald-Hartwig偶联反应的因素.
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| 关 键 词： | 哌嗪 苯并呋喃 甲酸乙酯 合成 Buchwald-Hartwig偶联 |
Synthesis of Ethyl 5-(4-tert-Butyloxycarbonyl-1-piperazinyl)benzofuran-2-carboxylate |
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| Feng Jing,Wang Chengyun,Zhou Changkai,Zuo Hujin,Shen Yongjia. Synthesis of Ethyl 5-(4-tert-Butyloxycarbonyl-1-piperazinyl)benzofuran-2-carboxylate[J]. Chinese Journal of Organic Chemistry, 2011, 31(2) |
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| Authors: | Feng Jing Wang Chengyun Zhou Changkai Zuo Hujin Shen Yongjia |
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| Affiliation: | Feng,Jing Wang,Chengyun Zhou,Changkai Zuo,Hujin Shen,Yongjia*(Laboratory for Advanced Materials,Institute of Fine Chemicals,East China University of Science and Technology,Shanghai 200237) |
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| Abstract: | Buchwald-Hartwig coupling reaction between ethyl 5-bromobenzofuran-2-carboxylate and tert-butyl piperazine-1-carboxylate was studied.When Pd(OAc)2/BINAP was employed as catalyst and Cs2CO3 as base,the major reaction product was ethyl 5-(4-tert-butyloxycarbonyl-1-piperazinyl)benzofuran-2-carboxylate,with a reaction conversion rate of 70%.While Pd(dba)2/P(t-Bu)3 was employed as catalyst and potassium tert-butoxide as base,nearly no ethyl 5-(4-tert-butyloxycarbonyl-1-piperazinyl)benzofuran-2-carboxylate was ob... |
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| Keywords: | piperazine benzofuran ethyl formate synthesis Buchwald-Hartwig coupling reaction |
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