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Analytical approaches to investigate transmitter content and release from single secretory vesicles |
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| Authors: | Donna M. Omiatek Ann-Sofie Cans Michael L. Heien Andrew G. Ewing |
| Affiliation: | 1. Department of Chemistry, The Pennsylvania State University, University Park, PA, 16802, USA 2. Department of Chemical and Biological Engineering, Chalmers University of Technology, 41296, G?teborg, Sweden 3. Department of Chemistry, University of Gothenburg, 41296, G?teborg, Sweden |
| Abstract: | The vesicle serves as the primary intracellular unit for the highly efficient storage and release of chemical messengers triggered during signaling processes in the nervous system. This review highlights conventional and emerging analytical methods that have used microscopy, electrochemistry, and spectroscopy to resolve the location, time course, and quantal content characteristics of neurotransmitter release. Particular focus is on the investigation of the synaptic vesicle and its involvement in the fundamental molecular mechanisms of cell communication. |
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