Intermolecular multiple-quantum coherence NMR signals modulated by double distant dipolar fields

A modified CRAZED pulse sequence was applied to obtain the intermolecular multiple-quantum coherence NMR signals from double distant dipolar fields in highly polarized spin systems. Complete theoretical analyses were explicitly derived from the dipolar field treatment combined with product operator formalism. Two typical samples containing several different components were chosen for the experimental verifications. The computer simulations and experimental observations are consistent with the theoretical predictions. The results presented herein provide a convenient way to understand the combined effects of multiple distant dipolar fields from the different components in complicated chemical or biological solutions. When experimental conditions such as selective radio-frequency pulses are not optimal, it may be helpful to identify possible unexpected signals or artefacts of high-resolution NMR spectroscopy in inhomogeneous fields.