Synthesis and Novel Properties of Alkyl Thiophosphoramidate Derivatives of Nucleosides |
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引用本文: | 苗志伟,付华,涂光忠,刘海,韩波,赵玉芬. Synthesis and Novel Properties of Alkyl Thiophosphoramidate Derivatives of Nucleosides[J]. 中国化学, 2002, 0(5) |
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作者姓名: | 苗志伟 付华 涂光忠 刘海 韩波 赵玉芬 |
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作者单位: | MIAO,Zhi Wei FU,Hua a TU,Guang Zhong b LIU Hai a HAN,Bo a ZHAO,Yu Fen ,a a Key Laboratory of Bioorganic Phosphorus Chemistry,Ministry of Education,Department of Chemistry,School |
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基金项目: | ProjectsupportedbytheNationalNaturalScienceFoundationofChina (Nos .2 990 2 0 0 3and 39870 4 15 ) ,theMinistryofScienceandTechnology ,theChineseMinistryofEducationandDoctorCandidateInnovationFoundationinTsinghuaUniversity (No .0 92 4 30 30 5 ) |
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摘 要: | Intruduction Thedevelopmentofnucleosideprodrugscapableofundergoingintracellularactivationtothecorrespondingnucleotidehasbecomeanareaofintenseinterest.1Sever alpurineandpyrimidinebasesandnucleosideanalogsareimportantweaponsintheanticancerandantiviralc…
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Synthesis and Novel Properties of Alkyl Thiophosphoramidate Derivatives of Nucleosides |
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Abstract: | |
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Keywords: | synthesis alkyl thiophosphoramidate nucleoside analogue hydrolysis reaction mechanism |
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