Rapid, non-targeted discovery of biochemical transformation and biomarker candidates in oncovirus-infected cell lines using LAESI mass spectrometry |
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| Authors: | Shrestha Bindesh Sripadi Prabhakar Walsh Callee M Razunguzwa Trust T Powell Matthew J Kehn-Hall Kylene Kashanchi Fatah Vertes Akos |
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| Institution: | Department of Chemistry, W. M. Keck Institute of Proteomics Technology and Applications, The George Washington University, Washington DC, USA. |
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| Abstract: | Finding insights into how viruses hijack metabolic processes and biomarkers for viral diseases often require hypotheses about target compounds and/or labelling techniques. Here we present a method based on laser ablation electrospray ionization mass spectrometry to rapidly identify potential protein and metabolite biomarkers of oncovirus infection in B lymphocytes. |
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