2-Methylthio-4,5,6,7-tetrahydro-1,2,4-triazolo[1,5-a]pyrimidin-5- and -7-Ones |
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Authors: | V. V. Lipson S. M. Desenko V. V. Borodina M. G. Shirobokova T. M. Karnozhitskaya V. I. Musatov S. V. Kravchenko |
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Affiliation: | (1) V. Ya. Danilevsky Institute of Endocrine Pathology Problems, Ukraine Academy of Medical Sciences, Kharkov, 61002, Ukraine;(2) STC Institute for Single Crystals, Kharkov, 61001, Ukraine |
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Abstract: | The cyclocondensation of methylcinnamates and arylidene derivatives of Meldrums acid with 3-amino-5-methylthio-1,2,4-triazole in DMF gives 2-methylthio-4,5,6,7-tetrahydro-1,2,4-triazolo[1,5-a]-pyrimidin-5-ones. The reaction involving arylidene derivatives of Meldrums acid or its synthetic equivalents in ethyl acetate with a catalytic amount of pyridine gives a mixture of 2-methylthio-4,5,6,7-tetrahydro-1,2,4-triazolo[1,5-a]pyrimidin-5- and -7-ones.__________Translated from Khimiya Geterotsiklicheskikh Soedinenii, No. 2, pp. 246–251, February, 2005. |
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Keywords: | 3-amino-5-methylthio-1,2,4-triazole arylidene derivatives of Meldrum /content/rh68862857128k7x/xxlarge8217.gif" alt=" rsquo" align=" BASELINE" BORDER=" 0" >s acid methylcinnamates partially hydrogenated 1,2,4-triazolo[1,5-a]pyrimidinones cyclocondensation |
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