Diastereoselective synthesis of gamma-lactams by a one-pot, four-component reaction |
| |
| Authors: | Wei Jingqiang Shaw Jared T |
| |
| Affiliation: | Broad Institute of Harvard and MIT, 7 Cambridge Center, Cambridge, Massachusetts 02142, USA. |
| |
| Abstract: | A new one-pot, four-component reaction (4CR) between amines, maleic anhydrides, aldehydes, and thiols has been discovered to form tetra- and pentasubstituted gamma-lactams with high diastereoselectivity. Each component is independently variable and employed in equivalent stoichiometry, producing only water as a byproduct. |
| |
| Keywords: | |
| 本文献已被 PubMed 等数据库收录！ |
|
