Palladium-catalyzed direct phosphonation of azoles with dialkyl phosphites |
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| Authors: | Hou Chaodong Ren Yunlai Lang Rui Hu Xiaoxue Xia Chungu Li Fuwei |
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| Institution: | State Key Laboratory for Oxo Synthesis and Selective Oxidation, Lanzhou Institute of Chemical Physics, Chinese Academy of Sciences, Lanzhou, 730000, China. |
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| Abstract: | The first Pd-catalyzed direct phosphonation of azoles with dialkyl phosphites has been achieved without addition of base or acid. This method involves the oxidative cleavage of C-H and P(O)-H bonds and represents an atom-efficiency alternative to the classical phosphonation of Ar-X. A Pd(II)/Pd(IV) mechanism has been studied and proposed. |
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