Molecular scaffolds using multiple orthogonal conjugations: applications in chemical biology and drug discovery |
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| Authors: | Beal David M Jones Lyn H |
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| Affiliation: | School of Biosciences, University of Kent, Canterbury, Kent, CT2 7NJ, UK. |
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| Abstract: | Heteromultifunctional scaffolds that harness sequential "click" reactions will find significant utility in the areas of chemical biology and chemically enabled/enhanced biotherapeutics ("chemologics"). Here we review the existing synthetic technologies that illustrate the considerable potential of the field. |
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| Keywords: | bioconjugation chemical biology click chemistry molecular scaffolds |
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