Cation binding to biomolecules |
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Authors: | Alberte Pullman Thomas Ebbesen Mohammed Rholam |
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Institution: | (1) Laboratoire de Biochimie Théorique associé au C.N.R.S., Institut de Biologie Physico-Chimique, 13, rue P. et M. Curie, F-75005 Paris, France |
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Abstract: | The binding of Zn2+ to the purine and pyrimidine bases of the nucleic acids was studied by SCFab initio (pseudopotential) computations. The order of affinity of the bases is guanine cytosine > adenine uracil. Many geometrical features of the binding are similar to those observed previously in the interaction of the bases with Na+. A new feature is the possibility of chelation by Zn2+ between N7 and the rotated NH2 group of adenine. |
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Keywords: | Zn2+ binding to nucleic acid bases |
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