双苯甲酰胺冠醚固定相的合成及毛细管柱气相色谱性能的研究

合成了一种新型的双苯甲酰胺冠醚固定相:(1S,2S)-1-(对苯甲酰胺基)苯基-2-苯甲酰胺基-16-冠-5,其结构经红外光谱、核磁共振、质谱及元素分析数据证实。考察了这种固定相的柱效、热稳定性、极性及选择性等色谱特性。该类固定相对极性位置异构体分离效果良好。由于冠醚上引入苯甲酰胺取代基,因而对苯胺类及不经衍生化的碱性化合物能特殊选择性地分离。

Synthesis and Capillary Column Gas Chromatographic Characterization of Double Benzamide Crown Ether Stationary Phase

A new kind of double benzamide crown ether:1S,2S-1-p-(benzamide)phenyl,2-Benzamide-16-crown-5 was synthesized for use as stationary phases in capillary column gas chromatography.Its structure was confirmed by IR,¹H NMR,MS and elemental analysis.The chromatographic characteristics,including column efficiency,thermal stability,polarity and selectivity were studied.Excellent selectivity was obtained for the separations of polar position isomers.The benzamide substituent group on crown ether makes the stationary phase have special selectivity for separating anilines and other basic compounds without derivatization.The factors which affect the separation mechanism, including dipole-dipole interactions,hydrogen bonding forces are discussed.