a Laboratoire de Pharmacognosie, Faculté de Pharmacie, av. J.B. Clément, 92296, Châtenay-Malabry Cedex, France
b Institut de Recherches Servier, 11 rue des Moulineaux, 92150, Suresnes, France
Abstract:
The behaviour of the synthetic (−)-16-(aminomethyl)eburnamenine (prepared from apovincamine) with formaldehyde was studied. Carrying out the reaction in acetic acid led to an original dimer, while in trifluoroacetic acid a 12-functionalized eburnamonine was isolated.