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Studies in the eburnane series: a new dimerization process
Authors:Guy Lewin  Corinne Schaeffer
Affiliation:

a Laboratoire de Pharmacognosie, Faculté de Pharmacie, av. J.B. Clément, 92296, Châtenay-Malabry Cedex, France

b Institut de Recherches Servier, 11 rue des Moulineaux, 92150, Suresnes, France

Abstract:The behaviour of the synthetic (−)-16-(aminomethyl)eburnamenine (prepared from apovincamine) with formaldehyde was studied. Carrying out the reaction in acetic acid led to an original dimer, while in trifluoroacetic acid a 12-functionalized eburnamonine was isolated.
Keywords:Alkaloids   indoles   dimers
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