Studies on Different Hydrolysis Procedures for Drugs of Abuse in Hair |
| |
| Authors: | Chen MA and Tong Hut ZHOU |
| |
| Affiliation: | Institute of Materia Medical Chinese Academy of Medical Sciences and Peking Union Medical College. Beijing 100050 |
| |
| Abstract: | Different hydrolysis and extraction procedures have been studied for the determinationof drugs of abuse in hair samples. The results showed that acid and enzymatic hydrolysis gave high extraction recoveries for 6-monoacetylmorphine. morphine. codeine and heroin. Enzymatic hydrolysis was more expensive. After alkaline hydrolysis. 6-monoacetylmorphine. a unique proofof heroin abuse. could not be detected and after methanolic extraction. the extract was dirty and the obtained chromatogram showed an interfering background. It is concluded that acid hydrolysis is the extraction method of choice. |
| |
| Keywords: | Drugs of abuse hydrolysis hair |
| 本文献已被 CNKI 等数据库收录！ |
