Suzuki coupling of aryl chlorides with phenylboronic acid in water, using microwave heating with simultaneous cooling |
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Authors: | Arvela Riina K Leadbeater Nicholas E |
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Institution: | Department of Chemistry, University of Connecticut, Unit 3060, 55 North Eagleville Road, Storrs, Connecticut 06269-3060, USA. |
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Abstract: | reaction: see text]. We present here a methodology for the Suzuki coupling of aryl chlorides with phenylboronic acid using Pd/C as a catalyst, water as a solvent, and microwave heating. We show that simultaneous cooling in conjunction with microwave heating prolongs the lifetime of the aryl chloride substrates during the course of the reaction and, as a result, yields of the desired biaryl as well as overall recovery of material can be increased. |
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