Pregnane glycosides, gymnepregosides G-Q from the roots of Gymnema alternifolium. |
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| Authors: | K Yoshikawa K Matsuchika K Takahashi M Tanaka S Arihara H C Chang J D Wang |
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| Institution: | Faculty of Pharmaceutical Sciences, Tokushima Bunri University, Japan. |
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| Abstract: | The structural elucidation of eleven new related polyoxypregnane glycosides, gymnepregosides G (1), H (2), I (3), J (4), K (5), L (6), M (7), N (8), O (9), P (10) and Q (11), from the roots of Gymnema alternifolium (Asclepiadaceae) was achieved by a detailed study of 1H- and 13C-NMR spectral data and chemical means. The results obtained for new compounds, 1-11, show that they are (20S)-pregn-6-ene-3 beta,5 alpha,8 beta,12 beta,14 beta,17 beta,20-heptaol 3-O-glycosides, and all the sugars at C-3 are beta(i-->4)-linked. Some of them possess benzoyl, (E)- and (Z)-cin-namoyl, and tigloyl residues as the ester linkages located at C-12 and/or C-20 of the aglycone. |
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