Total synthesis and absolute stereochemistry of pentenocin B, a novel interleukin-1 beta converting enzyme inhibitor |
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Authors: | Sugahara Tsutomu Fukuda Hayato Iwabuchi Yoshiharu |
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Affiliation: | Graduate School of Pharmaceutical Sciences, Tohoku University, Aobayama, Sendai 980-8578, Japan. iwabuchi@mail.pharm.tohoku.ac.jp |
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Abstract: | Four possible diastereomers of pentenocin B were synthesized in a stereocontrolled manner, and the first total synthesis of a natural enantiomer of (+)-pentenocin B unequivocally established the absolute stereochemistry to be 4S,5R,6R. |
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