Sequential and one-pot reactions of phenols with bromoalkynes for the synthesis of (Z)-2-bromovinyl phenyl ethers and benzo[b]furans |
| |
Authors: | Wang Shihua Li Pinhua Yu Lin Wang Lei |
| |
Institution: | Department of Chemistry, Huaibei Normal University, Huaibei, Anhui 235000, PR China. |
| |
Abstract: | Benzob]furans were prepared in one pot based on the addition/palladium-catalyzed C-H bond functionalization of phenols with bromoalkynes. The addition reactions of phenols to bromoalkynes generated (Z)-2-bromovinyl phenyl ethers in high yields with excellent regio- and stereoselectivity. The obtained (Z)-2-bromovinyl phenyl ethers subsequently proceeded by intramolecular cyclization to afford 2-substituted benzob]furans in good yields through palladium-catalyzed direct C-H bond functionalizations. It is important to note that the transformation of phenols with bromoalkynes into benzob]furans could be carried out in one pot with a simple and efficient tandem procedure. |
| |
Keywords: | |
本文献已被 PubMed 等数据库收录! |
|