Highly enantioselective and regioselective substitution of Morita-Baylis-Hillman carbonates with nitroalkanes |
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| Authors: | Chen Guo-Ying Zhong Fangrui Lu Yixin |
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| Institution: | Department of Chemistry & Medicinal Chemistry Program, Life Sciences Institute, National University of Singapore, 3 Science Drive 3, Republic of Singapore, 117543. |
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| Abstract: | A highly enantioselective and regioselective substitution reaction of the Morita-Baylis-Hillman (MBH) carbonates with nitroalkanes catalyzed by a quinidine-derived tertiary amine-thiourea catalyst has been developed. The described method, which is different from most organocatalytic allylic substitutions of the MBH adducts to date, represents a novel approach to regioselectively functionalize the MBH adducts. |
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