Iron-catalyzed oxidative monoarylation of primary amines with organozinc reagents |
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Authors: | Nakamura Yuki Ilies Laurean Nakamura Eiichi |
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Affiliation: | Department of Chemistry, School of Science, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-0033. |
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Abstract: | The reaction of a primary zinc amide with a diorganozinc reagent gives a secondary amine in the presence of Fe(acac)(3) as a catalyst and 1,2-dichloroisobutane (DCIB) as an oxidant. Halogen groups such as F, Cl, Br, and I are tolerated well. The dichloride oxidant and heat are essential to achieve the C-N bond formation presumably from a catalytic iron intermediate species bearing aryl and amido groups. |
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