Stereoselective preparation of conjugated E-enynes from E-vinylic tellurides and terminal alkynes via Sonogashira cross-coupling |
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| Authors: | Zeni Gilson Alves Diego Pena Jesus M Braga Antonio L Stefani Helio A Nogueira Cristina W |
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| Affiliation: | Departamento de Quimica, Laboratório de Bioquímica Toxicológica, UFSM, Santa Maria, RS, Brazil 97105-900. gzeni@quimica.ufsm.br |
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| Abstract: | E-Vinylic tellurides undergo a direct cross-coupling reaction with terminal alkynes in the presence of palladium(II)/CuI in Et(3)N at room temperature to give E-enynes in good yields. The methodology represents a general and efficient protocol for carrying out the synthesis of E-enynes under mild conditions with complete retention of configuration. |
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