Microwave-assisted synthesis of new polysubstituted dienaminoesters and their cyclization to 3-bromo-2(1H)-pyridinones |
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| Authors: | Adams Jeff Hardin Alison Vounatsos Filisaty |
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| Institution: | Chemistry Process Research and Development, Custom Synthesis Laboratory, Amgen Inc., Thousand Oaks, California 91320, USA. |
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| Abstract: | A microwave-assisted, telescoped synthesis, involving a Michael-type addition followed by intramolecular cyclization, provides an effective entry to the polysubstituted 3-bromo-2(1H)-pyridinone core. |
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