| 三个有机锡2，2'-联苯二甲酸酯的微波溶剂热合成、结构及体外抗癌活性 |
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| 引用本文： | 易思佳,贺霞,谷淑琪,邓哲宇,李嘉鸿,庾江喜,张复兴,朱小明.三个有机锡2，2'-联苯二甲酸酯的微波溶剂热合成、结构及体外抗癌活性[J].无机化学学报,2013,29(18). |
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| 作者姓名： | 易思佳 贺霞 谷淑琪 邓哲宇 李嘉鸿 庾江喜 张复兴 朱小明 |
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| 作者单位： | 衡阳师范学院化学与材料科学学院, 金属有机新材料湖南省高校重点实验室, 功能金属有机化合物湖南省重点实验室, 湘江上游重金属污染监测与治理湖南省工程研究中心, 衡阳 421008 |
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| 基金项目： | 湖南省自然科学青年基金(No.2021JJ40010)、湖南省教育厅重点项目(No.19A070)、湖南省功能金属有机化合物重点实验室开放基金(No.2021HSKFJJ002)、湖南省高校科技创新团队支持计划、2020年衡阳市科技局项目(No.202002042081)和2022年度湖南省大学生创新创业训练计划一般项目(No.cxcy2022011)资助。 |
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| 摘 要： | 以 2，2''-联苯二甲酸(H2DPA)分别与双(三(2-甲基-2-苯基丙基)锡)氧化物、三环己基氢氧化锡和二丁基氧化锡反应，合成了3个有机锡2，2''-联苯二甲酸酯：((PhC(Me)2CH2)3Sn)2(DPA)] (1)、(Cy)3Sn(DPA)]n (2)和(n-Bu)2Sn(DPA)]n (3)。通过IR、NMR、元素分析、热重及X射线单晶衍射对配合物进行表征分析。配合物1、2、3均属单斜晶系，配合物1为双核结构，配合物2、3为一维链状结构，锡原子的配位数依次增大，分别为4、5、6。体外抗癌活性实验表明，配合物1、2、3对人肺癌细胞(NCI-H460)、人乳腺腺癌细胞(MCF-7)、人肝癌细胞(HepG2)的增殖具有较强的抑制作用。
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| 关 键 词： | 有机锡2，2''-联苯二甲酸酯 微波溶剂热合成 晶体结构 体外抗癌活性 |
| 收稿时间： | 2022/11/24 0:00:00 |
| 修稿时间： | 2023/3/24 0:00:00 |
Microwave solvothermal syntheses, crystal structures, and in vitro antitumor activity of three organotin 2,2'-biphenyl dicarboxylate |
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| YI Si-Ji,HE Xi,GU Shu-Qi,DENG Zhe-Yu,LI Jia-Hong,YU Jiang-Xi,ZHANG Fu-Xing,ZHU Xiao-Ming.Microwave solvothermal syntheses, crystal structures, and in vitro antitumor activity of three organotin 2,2'-biphenyl dicarboxylate[J].Chinese Journal of Inorganic Chemistry,2013,29(18). |
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| Authors: | YI Si-Ji HE Xi GU Shu-Qi DENG Zhe-Yu LI Jia-Hong YU Jiang-Xi ZHANG Fu-Xing ZHU Xiao-Ming |
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| Institution: | Hunan Engineering Research Center for Monitoring and Treatment of Heavy Metals Pollution in the Upper Reaches of Xiangjiang River, Key Laboratory of Functional Metal?Organic Compounds of Hunan Province, Key Laboratory of Organometallic New Materials, College of Hunan Province, College of Chemistry and Material Science, Hengyang Normal University, Hengyang, Hunan 421008, China |
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| Abstract: | Three organotin 2, 2'' biphenyl dicarboxylates, namely ((PhC(Me)2CH2)3Sn)2(DPA)] (1), (Cy)3Sn(DPA)]n (2), and (n-Bu)2Sn(DPA)]n (3), have been prepared by the microwave-assisted solvothermal reaction of 2,2''-biphenyl dicarboxylic acid (H2DPA) with bis(tri(2-methyl-2-phenyl)propyl)tin oxide, tricyclohexyltin hydroxide, and dibutyltin oxide, respectively. Complexes 1-3 have been characterized by IR, NMR, elemental analysis, and thermogravimetry, and the crystal structures have been determined by X-ray diffraction. The crystals of 1-3 belong to the monoclinic system. Due to the influence of alkyl group steric, the steric resistance of the group for PhC(Me)2CH2 (1) > Cy (2) > n-Bu (3), the coordination number of tin atoms of complexes 1-3 increases successively, and the coordination number of tin atoms are 4, 5, and 6, respectively. Complex 1 has a binuclear structure, and complexes 2 and 3 are 1D chain structures. The antitumor activity shows that complexes 1-3 have higher activities than cisplatin in Human lung cancer cells (NCI-H460), human breast adenocarcinoma cells (MCF-7), and human liver cancer cells (HepG2) line in vitro. |
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| Keywords: | organotin 2 2''-biphenyldicarboxylate microwave solvothermal synthesis crystal structure in vitro antitumor activity |
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