A COMPARATIVE STUDY OF PHOTODYNAMIC OXIDATION AND RADIOFREQUENCY-DISCHARGE-GENERATED 1O2 OXIDATION OF GUANOSINE |
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| Authors: | A. Kornhauser N. I. Krinsky P.-K. C. Huang D. C. Clagett |
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| Affiliation: | Department of Biochemistry and Pharmacology, Tufts University School of Medicine, Boston, Massachusetts 02111, U.S.A.;Departments of Chemistry and Medicinal Chemistry, Northeastern University, Boston, Massachusetts 02115, U.S.A. |
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| Abstract: | Abstract— Guanosine-2-14C and guanosine-8-14C were subjected, under similar environmental conditions, to oxidation either by radiofrequency-discharge-generated singlet oxygen or by a methylene-blue-sensitized photodynamic reaction. The reaction products in both cases were compared chromatographically. The product distributions were not identical, indicating differing modes of oxidation in these two systems. It is suggested that both Type I and Type II oxidation mechanisms are operative in the photodynamic system, whereas only Type II-like reactions occur in the radio-frequency-discharge system. |
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