New antitumor principles, casearins A-F, for Casearia sylvestris Sw. (Flacourtiaceae) |
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Authors: | H Itokawa N Totsuka H Morita K Takeya Y Iitaka E P Schenkel M Motidome |
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Affiliation: | Department of Pharmacognosy, Tokyo College of Pharmacy, Japan. |
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Abstract: | New antitumor clerodane diterpenes, named casearins A-F, have been isolated from the leaves of Casearia sylvestris Sw. (Flacourtiaceae). These structures have been completely elucidated by two dimensional nuclear magnetic resonance, circular dichroism spectroscopy, X-ray analysis, and chemical evidences. |
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