Synthesis of β,γ-unsaturated primary amides from α,β-unsaturated acids and investigation of the mechanism |
| |
Authors: | Vassiliki Theodorou Marina GogouMaria Philippidou Valentine RagoussisGeorgios Paraskevopoulos Konstantinos Skobridis |
| |
Institution: | a Department of Chemistry, University of Ioannina, GR-45110, Greece b Department of Chemistry, University of Athens, Zografou, GR-15771 Athens, Greece |
| |
Abstract: | α,β-Unsaturated acids, through their acid chlorides, react with tritylamine in the presence of triethylamine under mild conditions, to afford in high yield and high regioselectivity the corresponding β,γ-unsaturated tritylamides. Detritylation with TFA generates quantitatively β,γ-unsaturated primary amides. An investigation of this deconjugative isomerization was performed. |
| |
Keywords: | Tritylamine β γ-Unsaturated N-tritylamides β γ-Unsaturated primary amides 3-Alkenamides Isomerization Detritylation |
本文献已被 ScienceDirect 等数据库收录! |
|