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Suzuki-Miyaura reactions of N-protected tribromopyrazoles. Efficient and site-selective synthesis of 3,4,5-triaryl-pyrazoles, 3,5-diaryl-4-bromopyrazoles and 5-aryl-3,4-dibromopyrazoles |
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| Authors: | Rasheed Ahmad Khera Asad Ali Hummera Rafique Munawar HussainJovana Tatar Aamer SaeedAlexander Villinger Peter Langer |
| Affiliation: | a Universität Rostock, Institut für Chemie, Albert Einstein Str. 3a, 18059 Rostock, Germany b Governmental College University, Faisalabad, Pakistan c University of Mardan, Mardan, N.W.F.P., Pakistan d Quaid-i-Azam University, Islamabad, Pakistan e University of Belgrade, Belgrade, Serbia f Leibniz-Institut für Katalyse an der Universität Rostock e.V., Albert Einstein Str. 29a, 18059 Rostock, Germany |
| Abstract: | Suzuki-Miyaura reactions of N-protected tribromopyrazoles were studied. The reactions proceed with excellent site-selectivity. The first attack occurs at position 5, while the second and third attack occur at positions 3 and 4, respectively. A variety of 3,4,5-triaryl-pyrazoles, 3,5-diaryl-4-bromopyrazoles, and 5-aryl-3,4-dibromopyrazoles were efficiently prepared. The products are not readily available by other methods. |
| Keywords: | Pyrazoles Catalysis Suzuki-Miyaura reaction Regioselectivity Palladium |
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