A new procedure for the preparation of 2-vinylindoles and their [4+2] cycloaddition reaction |
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| Authors: | Yaseen Ali Mosa MohamedFuyuhiko Inagaki Ryohei TakahashiChisato Mukai |
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| Institution: | Division of Pharmaceutical Sciences, Graduate School of Natural Science and Technology, Kanazawa University, Kakuma-machi, Kanazawa 920-1192, Japan |
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| Abstract: | A new approach for the synthesis of 2-vinylindole derivatives by 5-exo mode cyclization of 2-(3-silyloxymethylallenyl)anilines was developed. The starting allenylanilines were easily prepared by the Stille coupling of o-iodoaniline and allenylstannanes. The formed 2-vinylindole derivatives were transformed into several carbazole derivatives via the 4+2] cycloaddition reaction with suitable dienophiles. |
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| Keywords: | Allenes SN2&rsquo reaction 2-Vinylindoles Diels-Alder reaction |
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